Previously, the National Center for Health Statistics identified differences in all drug overdose deaths by state and by sex in rural and non-rural areas. For this project, we quantified and compared rural opioid overdose mortality in the US and in UVM CORA’s primary service area (Figure 1) by state, sex, and substances involved, using publicly available data from the Centers for Disease Control and Prevention (CDC) Wide-ranging Online Data for Epidemiologic Research (WONDER) tool.